Eight of the easyJet routes will operate from the UK.
Liverpool will get thrice weekly services to Fuerteventura and Lanzarote, starting 2 and 3 November respectively, while Luton adds Sharm El Sheikh and Paphos, both also thrice weekly, from 3 and 4 November.
Stansted, meanwhile, sees the launch of Fuerteventura (twice weekly from 4 Nov) and Edinburgh adds Lyon (thrice weekly from 17 Dec).
The airline will also start two new routes from its biggest base, Gatwick, to Porto (daily from 2 Nov) and Hamburg (twice daily Saturdays from 2 Feb).
Elsewhere Rome Fiumicino gets daily services to Athens (15 Oct), Geneva and Madrid (both 26 Oct), and Amsterdam, Lisbon and Lamezia Terme (all 2 Nov).
Finally, a Madrid-Amsterdam service, operating twice daily on weekdays and daily at weekends, launches 2 November.
Andy Harrison, easyJet chief executive, said: ‘Times are tough for consumers, so we are proud to offer great year round holiday opportunities in fantastic places such as Paphos, Fuerteventura and Sharm El Sheikh for incredibly low prices.
‘easyJet is clearly the best choice for sun seekers, city breakers and business travellers alike.’
Separately Ryanair announced its first Portuguese and 33rd European base at Porto, where it will station two aircraft there and add four new routes, taking its total network at the airport to 16.
The new routes are Basel, Eindhoven, St Etienne and Tours, all of which launch in September, while the airline will also double Paris Beauvais frequencies to twice daily.
In total it will offer 50 daily return flights to/from Porto, carrying 1.5m passengers a year.
See also:
Ryanair freezes UK growth (23/06/2009)
Aer Lingus expands Gatwick network (09/06/2009)
easyJet reports increase in non-UK passengers (06/05/2009)
Flybe and easyJet add regional routes (20/04/2009)